The end of knight-errantry in GVHD studies.
نویسنده
چکیده
In this issue of Blood, Bolaños-Meade et al reported the results of the randomized phase 3 study Blood and Marrow Transplant Clinical Trials Network (BMTCTN) 0802. It compared the addition of mycophenolate mofetil to steroids vs steroids/placebo to treat newly diagnosed acute graft-versus-host disease (GVHD). Unfortunately, it failed to show a significant difference in outcomes.
منابع مشابه
تأثیر GVHD مزمن بر بقا بیماران لوسمی میلوئیدی حاد پس از پیوند سلول‌های بنیادی خون محیطی از خواهر یا برادر با HLA مشابه بدون تخلیه سلول T
Background : Graft versus host disease (GVHD) is among major complications of allogeneic hematopoietic stem cells transplantation, and also is an important factor affecting the outcome of transplantation. An increased incidence of GVHD has been suggested following allogeneic peripheral blood stem cells (PBSC) transplantation, however, how this affects survival is not yet well clear. In this stu...
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Chronic graft versus host disease (GVHD) remains the most common late complication of allogenic stem cell transplantation and the most frequent cause of morbidity and mortality in these patients. To control this condition, immunosuppressive drugs are usually administered at a high dose and for a long time, which may result in several side effects. 5 patients with clinically and histopathologica...
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Transfusion associated graft versus host disease(GVHD) is a serious clinical complication that occurs in some cases after blood and blood products transfusion. The mortality ratio of this disorder is very high and in over 90% of cases lead to patients’ death. The procedure routinely used to inhibit GVHD is inactivation of donor blood lymphocytes and prevention of their proliferation in recipien...
متن کاملTh1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets.
STAT4 and STAT6 are transcription factors that play crucial roles in responding to IL-12 and IL-4, respectively. STAT4 gene knockout (STAT4(-/-)) mice have markedly reduced Th1 responses and enhanced Th2 responses. STAT6(-/-) mice show the inverse phenotype. We compared the ability of bone marrow transplantation (BMT) with the inclusion of spleen cells from STAT6(-/-), STAT4(-/-), and wild-type...
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عنوان ژورنال:
- Blood
دوره 124 22 شماره
صفحات -
تاریخ انتشار 2014